Mawadah Mohammed Hassan jannah
Neurology resident, KFAFH, Saudi Arabia
Publications
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Research Article
Analyzing the Impact of Chronic Stress on Hippocampal Function: A Systematic Review
Author(s): Mawadah Mohammed Hassan jannah* and Moamen Abdelfadil Ismail
Background: Chronic stress alters hippocampal structure and function, leading to memory deficits and increased vulnerability to psychiatric disorders (McEwen, 2000; Lupien et al., 2009). Purpose: This systematic review synthesizes evidence from 25 peer-reviewed studies to examine how chronic stress impacts the hippocampus at morphological, molecular, and behavioral levels. Methods: A comprehensive search was conducted across PubMed, PsycINFO, and Google Scholar using keywords such as “chronic stress,” “hippocampus,” “HPA axis,” and “memory impairment.” Studies were included if they were empirical (spanning animal models, human neuroimaging, and clinical cohorts) and measured specific hippocampal outcomes. Data extraction and quality assessments were performed by two independent reviewers, and r.. Read More»