Role of Platelet-Rich Plasma in Female Sexual Health and Recovery: A Systematic Review with Psychophysical Implications

Abstract

Moamen Abdelfadil Ismail*, Saja Moraya Al Saleh, Seham Badawi Mdawi, Asma Mufareh Asiri, Rafaa Fahad Alghamdi, Hlaa Turki Bagarish, Kawther Hamid Rajab, Ghaliah Hassan Abduljabar, Najwan Hassan Abduljabar

Background: Female sexual dysfunction (FSD) and vaginal laxity are prevalent conditions that significantly affect women's quality of life. Platelet-rich plasma (PRP), an autologous regenerative therapy, has emerged as a novel, minimally invasive treatment for enhancing vaginal health and improving sexual function.

Objective: To systematically review the evidence on the efficacy and safety of PRP therapy in vaginal rejuvenation and treatment of FSD.

Methods: A comprehensive search was conducted across PubMed, Google Scholar, MDPI, and Springer for studies published between 2015 and 2024. Eligible studies included randomized controlled trials, observational studies, and systematic reviews assessing PRP's impact on sexual function and vaginal restoration. Data on patient outcomes, PRP protocols, and adverse events were extracted. Results: Out of 367 screened articles, 17 met inclusion criteria. PRP demonstrated positive outcomes in vaginal lubrication, orgasmic function, and dyspareunia reduction. However, heterogeneity in PRP preparation methods and limited long-term data were noted. Most studies reported minimal side effects.

Conclusion: PRP therapy appears to be a promising approach for improving sexual function and vaginal integrity in women. Nonetheless, further large-scale randomized trials with standardized protocols are necessary to establish definitive efficacy.