Diana Khedr
Department of Neurology Faculty of Medicine, Cairo University, Saudi Arabia
Publications
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Research
ASSESSMENT OF CHLORIDE INTRACELLULAR CHANNEL PROTEIN-1 (CLIC1) ANTIBODY AS A BIOMARKER IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS (MS): A-PILOT CASE-CONTROL STUDY FROM EGYPT
Author(s): Lamees A. Samy, Dalia Labib*, Mona Nada, Noha Ramadan and Diana Khedr
Background: Multiple sclerosis is a chronic inflammatory disorder of the central nervous system. This study aimed to assess the association between the serum level of chloride intracellular channel 1 (CLIC1) antibody and the potential role of it in the diagnosis of MS. Methods: We con-ducted a pilot case-control study involving 90 participants divided into three groups: relapsing remitting multiple sclerosis (RRMS) (n=49), secondary progressive multiple sclerosis (n=11), and healthy controls (n=30). Detailed disease characteristics using Expanded Disability Status Score (EDSS) and imaging biomarkers were assessed. Serum levels of chloride intracellular channel protein-1 (CLIC1) antibody were measured. Results: The study showed statistically significant difference of Anti-CLIC1 levels when compared between the three.. Read More»