Sarah Abdulwahab Khan
Anesthesia, Saudi Arabia
Publications
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Research Article
Effect of Dexmedetomidine as an Adjuvant to Spinal Anesthesia on Postoperative Pain and Hemodynamic Stability in Lower Limb Surgeries: systematic review
Author(s): Atef Eid Madkour Elsayed*, Ghadi saad aljuhani, Bader Abdullah Alharthi, Reham Sameer abu alhamayel, Ahmed Saad Alromaihi, Hassan Othman Abdullah Alshehri, Abdullah Saleh Alshumrani, Abid Hussain, Ahmed Abdullatif Badaoud, Ahmed Talal Alamoodi, Fatimah Hisham Aldahnim, Sarah Abdulwahab Khan, Fatemah aljeziri and Reema Awad A. Alahmadi
Background: Dexmedetomidine, an α2-adrenergic agonist, has emerged as a promising intrathecal adjuvant to spinal anaesthesia due to its analgesic and hemodynamic stabilizing properties. This systematic review evaluates the efficacy and safety of dexmedetomidine compared to opioids and placebo in lower limb surgeries. Methods: A comprehensive literature search was performed across PubMed, Embase, Scopus, Web of Science, and Google Scholar from 2011 to 2025. Randomized controlled trials (RCTs) comparing dexmedetomidine with other adjuvants or placebo in spinal anaesthesia for lower limb surgeries were included. Outcomes assessed were duration of analgesia, onset time of sensory block, hemodynamic stability, and adverse events. Risk of bias was evaluated using the Cochrane Risk of Bias 2.0 tool. Results: Out of .. Read More»