PSYCHOLOGICAL AND CARDIOVASCULAR IMPACTS OF PSORIASIS: A SYSTEMATIC REVIEW OF ADVERSE mOUTCOMES

Abstract

Atef Eid Madkour Elsayed*, Hala Abdulrahman Sindi, Dana Tariq Alsuwaidan, Zakryah Abdulrhman Jar, Fatimah Abdullah Hassin, Mustafa Suliman, Rose Raif Alosaimi, Raffal Hatem Falata, Maryam Abdulhadi Alomari, Mada Alghamdi and Tasneem Abdullah Alzahrani

Background: There is mounting evidence linking the chronic inflammatory condition psoriasis to an elevated risk of cardiovascular disease (CVD), which impacts millions of people around the globe. The results of the several research that have looked at this connection have been all over the map. In light of the expanding corpus of clinical evidence, researchers sought to elucidate the link between psoriasis and negative cardiovascular outcomes by doing a comprehensive analysis of cohort studies.

Methods: In order to find cohort studies published prior to January of 2024, a comprehensive literature search was conducted using 4 electronic databases: MEDLINE, EMBASE, SCI-Web of Science, as well as the Cochrane Library. Inclusion criteria required studies to examine psoriasis and cardiovascular outcomes

Results: We looked at data from 31 cohort studies that included 17,902,757 healthy controls and 665,009 people with psoriasis. Heart attacks, strokes, cardiovascular deaths, ischemic heart disease, and psoriasis all went hand in hand. thromboembolism, and arrhythmia. People with moderate to serious psoriasis were more likely to be affected than those with mild psoriasis. Both European and Asian populations showed increased cardiovascular risks, with no significant difference between them.

Conclusion: This systematic review provides strong evidence that Cardiovascular complications are increased in individuals with psoriasis. People suffering from moderate to serious psoriasis are at an especially high risk. Clinicians should keep an eye on their psoriasis patient' cardiovascular health and consider preventative measures to lower their risk of cardiovascular disease (CVD), according to these results.