Manar Alhussain A Alhifzi
College of Medicine, King Khalid University (KKU), Abha, Saudi Arabia
Publications
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Research
Author(s): Amel Mohammed toum Ali Babiker*, Marwa Hussein Said Ahmad Alhag, Mohamed toum Elfatih Musa Ali, Nawaf Mohammed Abdulrahman Samarqandi, Arwa Elrashid Mohammed Osman Hasan, Elsharif A Bazie, Suzan Mohammed Ahmed Hamid, Safa Ahmed Abdalla, Amel Hameza Mohammed Hameza, Shaimaa Osamah Mansour Salamah, Atheer Abdalhadi Mohamed Homadi, Hala Shareif Eltayeb, Hiba Mohammed Salih Ibrahim Mohammed and Manar Alhussain A Alhifzi
Background: The first 1,000 days of life represent a critical window for gut microbiome development. Increasing evidence suggests that early-life antibiotic exposure disrupts microbiome maturation, enhances the gut resistome, and predisposes children to adverse health outcomes. Objective: This systematic review aims to evaluate the effects of early-life antibiotic exposure on gut microbiome diversity, resistome amplification, and subsequent childhood health conditions such as allergies, obesity, and neurodevelopmental disorders. Methods: Following PRISMA 2020 guidelines, we systematically reviewed 10 peer-reviewed studies published from 2010–2024. Eligible studies included human infants or children exposed to systemic antibiotics in the first two years of life and assessed outcomes in microbiome composition, .. Read More»