Mohammed Abdulla AlShikh
Cardio, Saudi Arabia
Publications
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Research
The Effect of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors on Mortality and Hospitalization in Patients with Heart Failure with Reduced Ejection Fraction: A Systematic Review and Meta-analysis
Author(s): Atef Eid Madkour Elsayed*, Mohammed Abdulla AlShikh, Emad bani Alharbi, Lelyan Sami Alqurshi, Ghazi Awad A Al qahtani, Ehab Ali, Zaidah Moeteg AlQahtani, Hamad Abkar Hakami, Ahmed sami alqurashi, Saleh Taher Almubarak and Mohanad Atiah Alzahrani
Background: Heart failure with reduced ejection fraction (HFrEF) remains associated with high rates of hospitalization and mortality despite advances in guideline-directed therapy. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, initially developed for diabetes management, have emerged as a novel therapeutic option in heart failure. Objectives: This systematic review and meta-analysis aimed to evaluate the impact of SGLT2 inhibitors on mortality, hospitalization, surrogate outcomes, and patient-reported health status in individuals with HFrEF. Methods: A comprehensive search of PubMed, Scopus, Embase, Web of Science, and Cochrane CENTRAL was conducted (2015–2023). Eligible studies included randomized controlled trials and meta-analyses examining SGLT2 inhibitors in adults with HFrEF. Ten clinical trials an.. Read More»